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The Heart Is Deceitful Above All Things is a 2004 drama film co-written and directed by Asia Argento and starring Argento, Jimmy Bennett, Dylan Sprouse and Cole Sprouse (with Bennett and the Sprouse brothers sharing the role as Jeremiah). The screenplay by Argento and Alessandro Magania is based on JT LeRoy's novel of the same name. The film received a limited release in North America on March 10, 2006, shortly after Laura Albert was revealed to be the actual author of the JT LeRoy books.
The film concerns a tattered relationship between Sarah, a drug addict, and her young son, Jeremiah. Their life together is marked by Sarah's substance abuse. The title is taken from Jeremiah 17:9.